A2764 dihydrochloride

• CAT Number: I016828
• CAS Number: 861038-72-4
• Molecular Formula: C₁₅H₂₁Cl₃N₂O
• Molecular Weight: 351.70
• Purity: ≥95%
• Target: Potassium Channel
• IUPAC Name: 2-(5-chloroquinolin-8-yl)oxy-N,N-diethylethanamine;dihydrochloride
• InChI: InChI=1S/C15H19ClN2O.2ClH/c1-3-18(4-2)10-11-19-14-8-7-13(16)12-6-5-9-17-15(12)14;;/h5-9H,3-4,10-11H2,1-2H3;2*1H
• InChIKey: ZVRDPULCSHGKBD-UHFFFAOYSA-N
• SMILES: CCN(CC)CCOC1=C2C(=C(C=C1)Cl)C=CC=N2.Cl.Cl

A2764 dihydrochloride（Cat No.:I016828）is a potent and selective inhibitor of the enzyme 5-lipoxygenase (5-LOX), which plays a key role in the inflammatory process. By blocking 5-LOX, A2764 dihydrochloride reduces the production of leukotrienes, compounds that contribute to inflammation and allergic reactions. This compound has shown promise in preclinical studies for treating conditions such as asthma, allergic rhinitis, and other inflammatory diseases. Its selective action makes it a potential therapeutic candidate for targeting specific pathways involved in chronic inflammatory disorders, offering an alternative to traditional treatments.

Reference

[1]. Lengyel M, et al. Chemically Modified Derivatives of the Activator Compound Cloxyquin Exert Inhibitory Effect on TRESK (K2P18.1) Background Potassium Channel.Mol Pharmacol. 2019 Jun;95(6):652-660.