For research use only. Not for therapeutic Use.
A2793(CAT: I021079) is an inhibitor of TRESK (TWIK-related spinal cord K+ channel) with an IC50 value of 6.8 μM for mTRESK. Additionally, A2793 also inhibits TASK-1 (TWIK-related acid-sensitive K+ channel 1). These channels are potassium channels involved in regulating neuronal excitability and have been implicated in various neurological conditions. By inhibiting these channels, A2793 may modulate neuronal activity and potentially have therapeutic applications in neurological disorders.
| Catalog Number | I021079 |
| CAS Number | 88349-90-0 |
| Synonyms | A2793; A-2793; A2793; |
| Molecular Formula | C13H12ClNO3 |
| Purity | 98% |
| Target | Potassium Channel |
| Solubility | To be determined |
| Appearance | Solid powder |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| IUPAC Name | Ethyl 2-[(5-chloroquinolin-8-yl)oxy]acetate |
| InChI | InChI=1S/C13H12ClNO3/c1-2-17-12(16)8-18-11-6-5-10(14)9-4-3-7-15-13(9)11/h3-7H,2,8H2,1H3 |
| InChIKey | JEMXUSHXYOXNFL-UHFFFAOYSA-N |
| SMILES | O=C(OCC)COC1=C2N=CC=CC2=C(Cl)C=C1 |
| Reference | 1: Lengyel M, Erdélyi F, Pergel E, Bálint-Polonka Á, Dobolyi A, Bozsaki P, Dux M, Király K, Hegedűs T, Czirják G, Mátyus P, Enyedi P. Chemically Modified Derivatives of the Activator Compound Cloxyquin Exert Inhibitory Effect on TRESK (K2P18.1) Background Potassium Channel. Mol Pharmacol. 2019 Jun;95(6):652-660. doi: 10.1124/mol.118.115626. Epub 2019 Apr 12. PMID: 30979812. |
