A2B receptor antagonist 2

• CAT Number: I044421
• CAS Number: 784-90-7
• Molecular Formula: C12H15N5
• Molecular Weight: 229.28
• Purity: ≥95%
• Synonyms: 2-(4,6,7-trimethylquinazolin-2-yl)guanidine
• InChI: InChI=1S/C12H15N5/c1-6-4-9-8(3)15-12(17-11(13)14)16-10(9)5-7(6)2/h4-5H,1-3H3,(H4,13,14,15,16,17)
• InChIKey: JFQDHSRWWLJCBV-UHFFFAOYSA-N
• SMILES: CC1=CC2=C(N=C(N=C2C=C1C)N=C(N)N)C

A2B receptor antagonist 2 (compound 18) is an adenosine receptor A2B antagonist, with Ki values of 2.30 μM, 6.8 μM and 3.44 μM for rA1, rA2A and hA2B, respectively[1].

Reference

[1]. Thomas R Webb, et al. Quinazolines as adenosine receptor antagonists: SAR and selectivity for A2B receptors. Bioorg Med Chem. 2003 Jan 2;11(1):77-85.
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