For research use only. Not for therapeutic Use.
A2ti-2（Cat No.:I015191）is a small molecule inhibitor specifically designed to target and block the activity of atypical protein kinase C iota (aPKCι), an enzyme involved in cellular signaling pathways that regulate cell growth, survival, and polarity. By inhibiting aPKCι, A2ti-2 shows potential for therapeutic applications in cancer research, particularly in cancers where aPKCι is overexpressed and linked to tumor progression and metastasis. This compound aids in understanding aPKCι’s role in oncogenesis and offers promise as a targeted therapy option for aggressive and treatment-resistant cancers.
| Catalog Number | I015191 |
| CAS Number | 482646-13-9 |
| Molecular Formula | C₁₈H₁₈N₄O₂S |
| Purity | ≥95% |
| Target | Virus Protease |
| IUPAC Name | 2-[[5-[(2-methylphenoxy)methyl]-4-phenyl-1,2,4-triazol-3-yl]sulfanyl]acetamide |
| InChI | InChI=1S/C18H18N4O2S/c1-13-7-5-6-10-15(13)24-11-17-20-21-18(25-12-16(19)23)22(17)14-8-3-2-4-9-14/h2-10H,11-12H2,1H3,(H2,19,23) |
| InChIKey | DRZJLOOZLBTLAL-UHFFFAOYSA-N |
| SMILES | CC1=CC=CC=C1OCC2=NN=C(N2C3=CC=CC=C3)SCC(=O)N |
| Reference | [1]. Tummala R K Reddy, et al.Three-dimensional Pharmacophore Design and Biochemical Screening Identifies Substituted 1,2,4-triazoles as Inhibitors of the Annexin A2-S100A10 Protein Interaction. ChemMedChem. 2012 Aug;7(8):1435-46.<br>[2]. Andrew W Woodham, et al. Small Molecule Inhibitors of the Annexin A2 Heterotetramer Prevent Human Papillomavirus Type 16 Infection. J Antimicrob Chemother. 2015;70(6):1686-90. |
