For research use only. Not for therapeutic Use.
A6770 is an orally active, potent sphingosine 1-phosphate (S1P) lyase (S1PL) inhibitor. A6770 is phosphorylated and the phosphorylated form directly inhibits S1P lyased.A6770, a potential key metabolite of THI, induces a [3H]dhS1P increase[1][2].
A6770 causes concentration-dependent increases in [3H] dhS1P with the EC50 ranging from 30 to 200 μM under the normal condition[1].
A6770 leads to S1PL inhibition rather than SPHK activation or SPP inhibition[2].
A6770 (1, 10, 100mg/kg; po; single dose) induces reductions in peripheral lymphocyte number in rats[2]
| Catalog Number | I021121 |
| CAS Number | 1331754-16-5 |
| Synonyms | 1-[5-(hydroxymethyl)-1H-imidazol-2-yl]ethanone |
| Molecular Formula | C6H8N2O2 |
| Purity | ≥95% |
| InChI | InChI=1S/C6H8N2O2/c1-4(10)6-7-2-5(3-9)8-6/h2,9H,3H2,1H3,(H,7,8) |
| InChIKey | JXDVIQLWMKAZBS-UHFFFAOYSA-N |
| SMILES | CC(=O)C1=NC=C(N1)CO |
| Reference | [1]. Mamoru Ohtoyo, et al. Scintillation Proximity Assay to Detect the Changes in Cellular Dihydrosphingosine 1-Phosphate Levels. Lipids. 2016 Oct;51(10):1207-1216. [2]. Mamoru Ohtoyo, et al. Component of Caramel Food Coloring, THI, Causes Lymphopenia Indirectly via a Key Metabolic Intermediate. Cell Chem Biol. 2016 May 19;23(5):555-560. |
