For research use only. Not for therapeutic Use.
A939572 (Cat.No:I000191) is a selective, non-ATP competitive inhibitor of the cyclin-dependent kinase (CDK) 4/6. It is being studied for the treatment of various types of cancer, particularly those that involve the overexpression of cyclin D1. A939572 has shown potent anti-proliferative activity in preclinical studies and is currently undergoing clinical trials.
| Catalog Number | I000191 |
| CAS Number | 1032229-33-6 |
| Synonyms | 4-(2-chlorophenoxy)-N-(3-(methylcarbamoyl)phenyl)piperidine-1-carboxamide |
| Molecular Formula | C20H22ClN3O3 |
| Purity | ≥95% |
| Target | Stearoyl-CoA Desaturase (SCD) |
| Solubility | DMSO: ≥ 56 mg/mL |
| Storage | Store at -20℃ |
| IC50 | <4 nM (mSCD1); 37 nM (hSCD1) [1] |
| IUPAC Name | 4-(2-chlorophenoxy)-N-[3-(methylcarbamoyl)phenyl]piperidine-1-carboxamide |
| InChI | InChI=1S/C20H22ClN3O3/c1-22-19(25)14-5-4-6-15(13-14)23-20(26)24-11-9-16(10-12-24)27-18-8-3-2-7-17(18)21/h2-8,13,16H,9-12H2,1H3,(H,22,25)(H,23,26) |
| InChIKey | DPYTYQFYDLYWHZ-UHFFFAOYSA-N |
| SMILES | ClC1=CC=CC=C1OC2CCN(C(NC3=CC(C(NC)=O)=CC=C3)=O)CC2 |
| Reference | <p style=/line-height:25px/> <br>[1]. Xin Z, et al. Discovery of piperidine-aryl urea-based stearoyl-CoA desaturase 1 inhibitors. Bioorg Med Chem Lett. 2008 Aug 1;18(15):4298-302. <br>[2]. von Roemeling CA, et al. Stearoyl-CoA desaturase 1 is a novel molecular therapeutic target for clear cell renal cell carcinoma. Clin Cancer Res. 2013 May 1;19(9):2368-80. |
