For research use only. Not for therapeutic Use.
AA-T3A-C12 is an anisamide ligand-tethered lipidoid (AA-lipidoid). AA-T3A-C12 mediates great RNA delivery and transfection of activated fibroblasts[1].
AA-T3A-C12/siRNA LNP can enhance uptake of siRNA LNP by TGF-β-stimulated 3T3 fibroblasts[1].
AA-T3A-C12 LNP enables robust gene knockdown in activated fibroblasts[1].
AA-T3A-C12/siHSP47 LNP (siRNA dose of 5 μg/mouse, i.v., twice weekly for 2 weeks) significantly down-regulates HSP47 expression in fibrotic mice[1].
| Catalog Number | I041415 |
| CAS Number | 2938207-23-7 |
| Synonyms | N-[3-[bis[3-[bis(2-hydroxydodecyl)amino]propyl]amino]propyl]-4-methoxybenzamide |
| Molecular Formula | C65H126N4O6 |
| Purity | ≥95% |
| InChI | InChI=1S/C65H126N4O6/c1-6-10-14-18-22-26-30-34-41-60(70)55-68(56-61(71)42-35-31-27-23-19-15-11-7-2)53-39-51-67(50-38-49-66-65(74)59-45-47-64(75-5)48-46-59)52-40-54-69(57-62(72)43-36-32-28-24-20-16-12-8-3)58-63(73)44-37-33-29-25-21-17-13-9-4/h45-48,60-63,70-73H,6-44,49-58H2,1-5H3,(H,66,74) |
| InChIKey | ADWWRKPNPJUOGO-UHFFFAOYSA-N |
| SMILES | CCCCCCCCCCC(CN(CCCN(CCCNC(=O)C1=CC=C(C=C1)OC)CCCN(CC(CCCCCCCCCC)O)CC(CCCCCCCCCC)O)CC(CCCCCCCCCC)O)O |
| Reference | [1]. Han X, et al. Ligand-tethered lipid nanoparticles for targeted RNA delivery to treat liver fibrosis. Nat Commun. 2023 Jan 17;14(1):75. |
