For research use only. Not for therapeutic Use.
AAI101（Cat No.:I013206）is a novel β-lactamase inhibitor designed to combat resistance in Gram-negative bacteria, especially against enzymes that degrade β-lactam antibiotics. It enhances the effectiveness of cephalosporins and other β-lactam antibiotics, improving their efficacy against multidrug-resistant pathogens. AAI101 shows significant potential in restoring antibiotic activity, especially in treating infections caused by resistant Enterobacteriaceae. Its role in combination therapies aims to address growing antibiotic resistance issues, offering a promising approach for difficult-to-treat infections in clinical settings where traditional antibiotics have limited impact.
| Catalog Number | I013206 |
| CAS Number | 1001404-83-6 |
| Molecular Formula | C₁₁H₁₄N₄O₅S |
| Purity | ≥95% |
| Target | Bacterial |
| Solubility | DMSO: ≥ 113.3 mg/mL |
| IUPAC Name | (2S,3S,5R)-3-methyl-3-[(3-methyltriazol-3-ium-1-yl)methyl]-4,4,7-trioxo-4lambda6-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate |
| InChI | InChI=1S/C11H14N4O5S/c1-11(6-14-4-3-13(2)12-14)9(10(17)18)15-7(16)5-8(15)21(11,19)20/h3-4,8-9H,5-6H2,1-2H3/t8-,9+,11+/m1/s1 |
| InChIKey | HFZITXBUTWITPT-YWVKMMECSA-N |
| SMILES | C[C@@]1([C@@H](N2[C@H](S1(=O)=O)CC2=O)C(=O)[O-])CN3C=C[N+](=N3)C |
| Reference | [1]. Crandon JL, et al. In Vitro Activity of Cefepime/AAI101 and Comparators against Cefepime Non-susceptible Enterobacteriaceae. Pathogens. 2015 Aug 18;4(3):620-5.<br>[2]. Crandon JL, et al. In vivo activities of simulated human doses of cefepime and cefepime-AAI101 against multidrug-resistant Gram-negative Enterobacteriaceae. Antimicrob Agents Chemother. 2015 May;59(5):2688-94. |
