For research use only. Not for therapeutic Use.
AAPK-25（Cat No.:I018696）is a selective inhibitor of the AMP-activated protein kinase (AMPK), an enzyme that plays a critical role in cellular energy homeostasis. By inhibiting AMPK, AAPK-25 affects metabolic pathways related to glucose uptake, lipid metabolism, and mitochondrial biogenesis. This compound is used in research to study the regulation of energy balance in cells, particularly in relation to metabolic disorders such as diabetes and obesity. AAPK-25 provides valuable insights into AMPK’s function, offering potential therapeutic applications in the treatment of metabolic diseases and understanding the mechanisms of energy regulation.
| Catalog Number | I018696 |
| CAS Number | 2247919-28-2 |
| Molecular Formula | C₂₁H₁₃Cl₂N₃O₂S |
| Purity | ≥95% |
| Target | Aurora Kinase; Polo-like Kinase (PLK); Apoptosis |
| IUPAC Name | 6-[(3,4-dichlorobenzoyl)amino]-N-(1,3-thiazol-2-yl)naphthalene-2-carboxamide |
| InChI | InChI=1S/C21H13Cl2N3O2S/c22-17-6-4-15(11-18(17)23)19(27)25-16-5-3-12-9-14(2-1-13(12)10-16)20(28)26-21-24-7-8-29-21/h1-11H,(H,25,27)(H,24,26,28) |
| InChIKey | MRITYVDXXFOOAU-UHFFFAOYSA-N |
| SMILES | C1=CC2=C(C=CC(=C2)NC(=O)C3=CC(=C(C=C3)Cl)Cl)C=C1C(=O)NC4=NC=CS4 |
| Reference | [1]. Qi B, et al. Discovery of inhibitors of Aurora/PLK targets as anti-cancer agents. J Med Chem. 2019 Aug 5. |
