For research use only. Not for therapeutic Use.
Abacavir hydroxyacetate is an orally active inhibitor of IL-20 and PRINS. Abacavir hydroxyacetate reduces proliferation rate of skin in psoriasis as an immune modulator. Abacavir hydroxyacetate can be used for the research of inflammatory skin problems[1][2].
Abacavir hydroxyacetate (10-20 mg/kg; p.o. once) effectively controls psoriasis of mice[2].
| Catalog Number | I000529 |
| CAS Number | 1446418-48-9 |
| Synonyms | [(1S,4R)-4-[2-amino-6-(cyclopropylamino)purin-9-yl]cyclopent-2-en-1-yl]methyl 2-hydroxyacetate |
| Molecular Formula | C16H20N6O3 |
| Purity | ≥95% |
| InChI | InChI=1S/C16H20N6O3/c17-16-20-14(19-10-2-3-10)13-15(21-16)22(8-18-13)11-4-1-9(5-11)7-25-12(24)6-23/h1,4,8-11,23H,2-3,5-7H2,(H3,17,19,20,21)/t9-,11+/m1/s1 |
| InChIKey | ZBBZROWQLKCFQK-KOLCDFICSA-N |
| SMILES | C1CC1NC2=C3C(=NC(=N2)N)N(C=N3)C4CC(C=C4)COC(=O)CO |
| Reference | [1]. Guda A, et al. Investigational drugs in phase II clinical trials for moderate to severe plaque psoriasis – potential new treatments on the horizon. Expert Opin Investig Drugs. 2018 Nov;27(11):931-939. [2]. Menon, et al. CARBOCYCLIC NUCLEOSIDES AND THEIR PHARMACEUTICAL USE AND COMPOSITIONS. WO/2013/103601/Al. |
