For research use only. Not for therapeutic Use.
ABD957 is a potent and selective covalent inhibitor of the ABHD17 family of depalmitoylases, with an IC50 of 0.21 µM for ABHD17B. ABD957 can block N-Ras signaling and the growth of NRAS-mutant AML cells[1].
ABD957 (500 nM; pretreated for 1 h) attenuates N-Ras depalmitoylation in AML cells[1].
ABD957 (0.11 nM-10 μM; 72 h) blocks the signaling and proliferation of NRAS-mutant leukemia cells[1].
| Catalog Number | I045216 |
| CAS Number | 3007772-60-0 |
| Synonyms | 2-[8-[2-[[(3S)-4-[3-(dimethylsulfamoyl)pyrazole-1-carbonyl]-3-methylpiperazin-1-yl]methyl]-5-(trifluoromethyl)phenyl]-3,8-diazabicyclo[3.2.1]octan-3-yl]acetic acid |
| Molecular Formula | C27H36F3N7O5S |
| Purity | ≥95% |
| InChI | InChI=1S/C27H36F3N7O5S/c1-18-13-33(10-11-35(18)26(40)36-9-8-24(31-36)43(41,42)32(2)3)14-19-4-5-20(27(28,29)30)12-23(19)37-21-6-7-22(37)16-34(15-21)17-25(38)39/h4-5,8-9,12,18,21-22H,6-7,10-11,13-17H2,1-3H3,(H,38,39)/t18-,21?,22?/m0/s1 |
| InChIKey | ISNXAOFEMNFJCO-XTWGIRIWSA-N |
| SMILES | CC1CN(CCN1C(=O)N2C=CC(=N2)S(=O)(=O)N(C)C)CC3=C(C=C(C=C3)C(F)(F)F)N4C5CCC4CN(C5)CC(=O)O |
| Reference | [1]. Remsberg JR, et, al. ABHD17 regulation of plasma membrane palmitoylation and N-Ras-dependent cancer growth. Nat Chem Biol. 2021 Aug;17(8):856-864. |
