Abemaciclib metabolite M2

• CAT Number: I018959
• CAS Number: 1231930-57-6
• Molecular Formula: C25H28F2N8
• Molecular Weight: 478.54
• Purity: ≥95%
• Synonyms: 5-fluoro-4-(7-fluoro-2-methyl-3-propan-2-ylbenzimidazol-5-yl)-N-[5-(piperazin-1-ylmethyl)pyridin-2-yl]pyrimidin-2-amine
• InChI: InChI=1S/C25H28F2N8/c1-15(2)35-16(3)31-24-19(26)10-18(11-21(24)35)23-20(27)13-30-25(33-23)32-22-5-4-17(12-29-22)14-34-8-6-28-7-9-34/h4-5,10-13,15,28H,6-9,14H2,1-3H3,(H,29,30,32,33)
• InChIKey: IXGZDCRFGCEEBU-UHFFFAOYSA-N
• SMILES: CC1=NC2=C(N1C(C)C)C=C(C=C2F)C3=NC(=NC=C3F)NC4=NC=C(C=C4)CN5CCNCC5

Abemaciclib Metabolite M2(CAT: I018959) is one of the primary metabolites of Abemaciclib, a selective inhibitor of cyclin-dependent kinases 4 and 6 (CDK4/6) used in the treatment of certain types of breast cancer. The M2 metabolite is formed through the oxidation of the parent drug and retains biological activity, contributing to the overall pharmacological effect of Abemaciclib. The presence of the M2 metabolite is important for understanding the drug’s pharmacokinetics, including its metabolism, distribution, and excretion. Research into Abemaciclib Metabolite M2 is essential for optimizing dosing regimens, assessing drug efficacy, and evaluating potential side effects during cancer therapy.