For research use only. Not for therapeutic Use.
ABMA（Cat No.:I017143）, or 4-Amino-2-butylamino-6-methylpyrimidine, is a small molecule with research significance due to its potential as an efflux pump inhibitor, especially in studies targeting multidrug-resistant bacteria. By inhibiting bacterial efflux pumps, ABMA may help increase the efficacy of antibiotics that are otherwise expelled from bacterial cells, allowing higher intracellular drug concentrations and improved antibacterial activity. This compound’s role in combating antibiotic resistance has spurred interest in its applications in combination therapies, where it could support the action of existing antibiotics against resistant bacterial strains, enhancing treatment outcomes.
| Catalog Number | I017143 |
| CAS Number | 332108-65-3 |
| Molecular Formula | C₁₈H₂₄BrNO |
| Purity | ≥95% |
| Target | Dengue virus |
| IUPAC Name | N-[(5-bromo-2-methoxyphenyl)methyl]adamantan-1-amine |
| InChI | InChI=1S/C18H24BrNO/c1-21-17-3-2-16(19)7-15(17)11-20-18-8-12-4-13(9-18)6-14(5-12)10-18/h2-3,7,12-14,20H,4-6,8-11H2,1H3 |
| InChIKey | UCAHJECAHMOSHI-UHFFFAOYSA-N |
| SMILES | COC1=C(C=C(C=C1)Br)CNC23CC4CC(C2)CC(C4)C3 |
| Reference | [1]. Wu Y, et al. ABMA, a small molecule that inhibits intracellular toxins and pathogens by interfering with late endosomal compartments.<br>[2]. Wu Y, et al. DABMA: A Derivative of ABMA with Improved Broad-Spectrum Inhibitory Activity of Toxins and Viruses. ACS Med Chem Lett. 2019 Jul 2;10(8):1140-1147. |
