For research use only. Not for therapeutic Use.
ABP688 is a high affinity human mGluR5 antagonist with anKi of 1.7 nM. Radioisotope-labeled ABP688 can be used as a PET tracer for clinical imaging of the mGlu5 receptor[1].
| Catalog Number | I011143 |
| CAS Number | 924298-51-1 |
| Synonyms | (E)-N-methoxy-3-[2-(6-methylpyridin-2-yl)ethynyl]cyclohex-2-en-1-imine |
| Molecular Formula | C15H16N2O |
| Purity | ≥95% |
| InChI | InChI=1S/C15H16N2O/c1-12-5-3-7-14(16-12)10-9-13-6-4-8-15(11-13)17-18-2/h3,5,7,11H,4,6,8H2,1-2H3/b17-15+ |
| InChIKey | CNNZLFXCUQLKOB-BMRADRMJSA-N |
| SMILES | CC1=NC(=CC=C1)C#CC2=CC(=NOC)CCC2 |
| Reference | [1]. Hintermann S, et al. ABP688, a novel selective and high affinity ligand for the labeling of mGlu5 receptors: identification, in vitro pharmacology, pharmacokinetic and biodistribution studies. Bioorg Med Chem. 2007 Jan 15;15(2):903-14. |
