For research use only. Not for therapeutic Use.
ABT-072（Cat No.:I000711）is a non-nucleoside reverse transcriptase inhibitor (NNRTI) developed for the treatment of hepatitis C virus (HCV) infections. It targets the NS5B polymerase, a critical enzyme in HCV RNA replication, effectively halting viral replication. ABT-072 exhibits potent antiviral activity across multiple HCV genotypes and has been investigated as part of combination therapies to enhance efficacy and reduce resistance. Its favorable pharmacokinetic profile and high barrier to resistance make it a valuable compound in antiviral research, contributing to the development of next-generation therapies for chronic HCV management.
| Catalog Number | I000711 |
| CAS Number | 1132936-00-5 |
| Synonyms | ABT-072; ABT 072; ABT072.;(E)-N-(4-(3-(tert-butyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-methoxystyryl)phenyl)methanesulfonamide |
| Molecular Formula | C24H27N3O5S |
| Purity | ≥95% |
| Target | HCV |
| Solubility | Soluble in DMSO |
| Storage | -20°C |
| IUPAC Name | N-[4-[(E)-2-[3-tert-butyl-5-(2,4-dioxopyrimidin-1-yl)-2-methoxyphenyl]ethenyl]phenyl]methanesulfonamide |
| InChI | InChI=1S/C24H27N3O5S/c1-24(2,3)20-15-19(27-13-12-21(28)25-23(27)29)14-17(22(20)32-4)9-6-16-7-10-18(11-8-16)26-33(5,30)31/h6-15,26H,1-5H3,(H,25,28,29)/b9-6+ |
| InChIKey | XMZSTQYSBYEENY-RMKNXTFCSA-N |
| SMILES | CC(C)(C)C1=CC(=CC(=C1OC)/C=C/C2=CC=C(C=C2)NS(=O)(=O)C)N3C=CC(=O)NC3=O |
| Reference | </br>1:Assessing Supersaturation and Its Impact on In Vivo Bioavailability of a Low-Solubility Compound ABT-072 With a Dual pH, Two-Phase Dissolution Method. Shi Y, Erickson B, Jayasankar A, Lu L, Marsh K, Menon R, Gao P.J Pharm Sci. 2016 Sep;105(9):2886-95. doi: 10.1016/j.xphs.2016.04.036. Epub 2016 Jun 16. PMID: 27321234 </br>2:A phase 2a trial of 12-week interferon-free therapy with two direct-acting antivirals (ABT-450/r, ABT-072) and ribavirin in IL28B C/C patients with chronic hepatitis C genotype 1. Lawitz E, Poordad F, Kowdley KV, Cohen DE, Podsadecki T, Siggelkow S, Larsen L, Menon R, Koev G, Tripathi R, Pilot-Matias T, Bernstein B.J Hepatol. 2013 Jul;59(1):18-23. doi: 10.1016/j.jhep.2013.02.009. Epub 2013 Feb 22. PMID: 23439262 |
