ABT-224

• CAT Number: I000759
• CAS Number: 287399-47-7
• Molecular Formula: C14H15N3O
• Molecular Weight: 241.29
• Purity: ≥95%
• Synonyms: ABT-224; AU-224; ABT224; AU224; ABT 224; AU 224;piperidin-1-yl(quinoxalin-6-yl)methanone
• Target: 5-HT4 agonist
• Solubility: Soluble in DMSO
• Storage: 0 - 4°Cfor short term (days to weeks), or -20 °C for long term (months).
• IUPAC Name: butyl 2-[4-[(4-amino-5-chloro-2-methoxybenzoyl)amino]piperidin-1-yl]acetate
• InChI: InChI=1S/C14H15N3O/c18-14(17-8-2-1-3-9-17)11-4-5-12-13(10-11)16-7-6-15-12/h4-7,10H,1-3,8-9H2
• InChIKey: ANDGGVOPIJEHOF-UHFFFAOYSA-N
• SMILES: O=C(N1CCCCC1)C2=CC=C3N=CC=NC3=C2

ABT-224 (CAT: I000759) is a selective 5-HT4 receptor agonist, investigated for its potential therapeutic application in treating constipation. By activating 5-HT4 receptors in the gastrointestinal tract, it enhances peristalsis, promotes intestinal motility, and facilitates bowel movements. This targeted mechanism positions ABT-224 as a promising candidate for addressing gastrointestinal disorders characterized by reduced motility. ABT-224 is particularly significant in gastrointestinal research, where it supports the exploration of serotonergic pathways and the development of effective treatments for constipation and related motility disorders.