ABT 239 tartrate

• CAT Number: I012852
• CAS Number: 460748-71-4
• Molecular Formula: C22H22N2O.C4H6O6
• Molecular Weight: 480.51
• Purity: ≥95%
• IUPAC Name: (2R,3R)-2,3-dihydroxybutanedioic acid;4-[2-[2-[(2R)-2-methylpyrrolidin-1-yl]ethyl]-1-benzofuran-5-yl]benzonitrile
• InChI: InChI=1S/C22H22N2O.C4H6O6/c1-16-3-2-11-24(16)12-10-21-14-20-13-19(8-9-22(20)25-21)18-6-4-17(15-23)5-7-18;5-1(3(7)8)2(6)4(9)10/h4-9,13-14,16H,2-3,10-12H2,1H3;1-2,5-6H,(H,7,8)(H,9,10)/t16-;1-,2-/m11/s1
• SMILES: C[C@@H]1CCCN1CCC2=CC3=C(O2)C=CC(=C3)C4=CC=C(C=C4)C#N.[C@@H]([C@H](C(=O)O)O)(C(=O)O)O

Potent and selective histamine H3 receptor antagonist or inverse agonist; a highly recommended tool for animal research into H3 antagonist / inverse agonist

Reference

TA Esbenshade et al. Pharmacological properties of ABT-239 [4-(2-{2-[(2R)-2-Methylpyrrolidinyl]ethyl}-benzofuran-5-yl)benzonitrile]: I. Potent and selective histamine H3 receptor antagonist with drug-like properties. J. Ph. Exp. Ther. 2005, 313, 165.

 

GB Fox et al. Pharmacological properties of ABT-239 : II. Neurophysiological characterization and broad preclinical efficacy in cognition and schizophrenia of a potent and selective histamine H3 receptor antagonist. J. Ph. Exp. Ther. 2005, 313,  176–90. 

 

M Cowart et al. 4-(2-[2-(2(R)-methylpyrrolidin-1-yl)ethyl]benzofuran-5-yl)benzonitrile and related 2-aminoethylbenzofuran H3 receptor antagonists potently enhance cognition and attention. J. Med. Chem. 2005, 48 (1), 38–55.