ABT-737

• CAT Number: I005120
• CAS Number: 852808-04-9
• Molecular Formula: C₄₂H₄₅ClN₆O₅S₂
• Molecular Weight: 813.43
• Purity: ≥95%
• Synonyms: ABT-737; ABT 737; ABT737;4-[4-[[2-(4-chlorophenyl)phenyl]methyl]piperazin-1-yl]-N-[4-[[(2R)-4-(dimethylamino)-1-phenylsulfanylbutan-2-yl]amino]-3-nitrophenyl]sulfonylbenzamide
• Target: Autophagy
• Solubility: DMSO ≥160mg/mL Water <1.2mg/mL Ethanol <1.2mg/mL
• Storage: 3 years -20C powder
• IC50: 78.7 nM(Bcl-xL); 30.3 nM(Bcl-2); 197.8 nM(Bcl-w)
• IUPAC Name: 4-[4-[[2-(4-chlorophenyl)phenyl]methyl]piperazin-1-yl]-N-[4-[[(2R)-4-(dimethylamino)-1-phenylsulfanylbutan-2-yl]amino]-3-nitrophenyl]sulfonylbenzamide
• InChI: InChI=1S/C42H45ClN6O5S2/c1-46(2)23-22-35(30-55-37-9-4-3-5-10-37)44-40-21-20-38(28-41(40)49(51)52)56(53,54)45-42(50)32-14-18-36(19-15-32)48-26-24-47(25-27-48)29-33-8-6-7-11-39(33)31-12-16-34(43)17-13-31/h3-21,28,35,44H,22-27,29-30H2,1-2H3,(H,45,50)/t35-/m1
• InChIKey: HPLNQCPCUACXLM-PGUFJCEWSA-N
• SMILES: CN(C)CCC(CSC1=CC=CC=C1)NC2=C(C=C(C=C2)S(=O)(=O)NC(=O)C3=CC=C(C=C3)N4CCN(CC4)CC5=CC=CC=C5C6=CC=C(C=C6)Cl)[N+](=O)[O-]

ABT-737(CAT: I005120) is a potent BH3 mimetic inhibitor targeting anti-apoptotic proteins Bcl-xL, Bcl-2, and Bcl-w, with EC50 values of 78.7 nM, 30.3 nM, and 197.8 nM, respectively. By mimicking the BH3 domain of pro-apoptotic proteins, it disrupts the interaction between anti-apoptotic Bcl-2 family proteins and their pro-apoptotic counterparts, promoting apoptosis in cancer cells. ABT-737 is particularly significant in oncology research, where it is used to study apoptosis regulation and to explore therapeutic strategies for cancers with overexpression of Bcl-2 family proteins, such as lymphomas and solid tumors. Its specificity and potency make it a valuable tool for advancing targeted cancer therapies.