For research use only. Not for therapeutic Use.
ABT-869(Cat No.:I004909)is a potent multi-targeted tyrosine kinase inhibitor that primarily inhibits vascular endothelial growth factor receptor (VEGFR) and platelet-derived growth factor receptor (PDGFR) signaling pathways. By blocking these receptors, ABT-869 disrupts angiogenesis and tumor growth, making it a valuable compound in cancer research. It is particularly effective in targeting solid tumors, such as those found in liver and kidney cancers, where abnormal angiogenesis plays a key role. ABT-869’s broad inhibition of kinases involved in tumor vasculature makes it a promising agent for developing anti-cancer therapies.
Catalog Number | I004909 |
CAS Number | 796967-16-3 |
Synonyms | 1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-(2-fluoro-5-methylphenyl)urea |
Molecular Formula | C₂₁H₁₈FN₅O |
Purity | ≥95% |
Target | VEGFR |
Solubility | DMSO ≥72mg/mL Water <1.2mg/mL Ethanol ≥4.6mg/mL |
Storage | 3 years -20℃ powder |
IC50 | 4 nM/3 nM/3 nM/4 nM /66 nM(KDR/CSF-1R/Flt-1/Flt-3PDGFRβ) |
IUPAC Name | 1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-(2-fluoro-5-methylphenyl)urea |
InChI | InChI=1S/C21H18FN5O/c1-12-5-10-16(22)18(11-12)25-21(28)24-14-8-6-13(7-9-14)15-3-2-4-17-19(15)20(23)27-26-17/h2-11H,1H3,(H3,23,26,27)(H2,24,25,28) |
InChIKey | MPVGZUGXCQEXTM-UHFFFAOYSA-N |
SMILES | CC1=CC(=C(C=C1)F)NC(=O)NC2=CC=C(C=C2)C3=C4C(=CC=C3)NN=C4N |
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