ABT-888

• CAT Number: I005439
• CAS Number: 912445-05-7
• Molecular Formula: C₁₃H₁₆N₄O.2HCl
• Molecular Weight: 317.21
• Purity: ≥95%
• Synonyms: ABT-888;ABT888;ABT 888
• Target: Epigenetics
• Solubility: DMSO: ≥ 3.2 mg/mL
• Storage: Store at -20°C
• IC50: 5.2 nM(Ki for PARP1); 2.9 nM(Ki for PARP2)
• IUPAC Name: 2-[(2R)-2-methylpyrrolidin-2-yl]-1H-benzimidazole-4-carboxamide;dihydrochloride
• InChI: InChI=1S/C13H16N4O.2ClH/c1-13(6-3-7-15-13)12-16-9-5-2-4-8(11(14)18)10(9)17-12;;/h2,4-5,15H,3,6-7H2,1H3,(H2,14,18)(H,16,17);2*1H/t13-;;/m1../s1
• InChIKey: DSBSVDCHFMEYBX-FFXKMJQXSA-N
• SMILES: C[C@@]1(CCCN1)C2=NC3=C(C=CC=C3N2)C(=O)N.Cl.Cl

ABT-888 (Cat No.:I005439) is a potent and selective inhibitor of poly (ADP-ribose) polymerase (PARP), an enzyme involved in DNA repair. By inhibiting PARP, ABT-888 prevents cancer cells from repairing damaged DNA, leading to cell death, especially in tumors with deficiencies in other DNA repair pathways, such as BRCA mutations. It is primarily used in cancer research to explore combination therapies, where ABT-888 enhances the efficacy of chemotherapy and radiation treatments. Veliparib is being investigated for its potential in treating various cancers, including breast, ovarian, and lung cancers.

Reference

[1]. Donawho CK, et al. ABT-888, an orally active poly(ADP-ribose) polymerase inhibitor that potentiates DNA-damaging agents in preclinical tumor models. Clin Cancer Res. 2007 May 1;13(9):2728-37. 


[2]. Penning TD, et al. Discovery of the Poly(ADP-ribose) polymerase (PARP) inhibitor 2-[(R)-2-methylpyrrolidin-2-yl]-1H-benzimidazole-4-carboxamide (ABT-888) for the treatment of cancer. J Med Chem. 2009 Jan 22;52(2):514-23. 


[3]. Albert JM, et al. Inhibition of poly(ADP-ribose) polymerase enhances cell death and improves tumor growth delay in irradiated lung cancer models. Clin Cancer Res. 2007 May 15;13(10):3033-42.