For research use only, not for therapeutic use.
ABT-888 (Cat No.:I005439) is a potent and selective inhibitor of poly (ADP-ribose) polymerase (PARP), an enzyme involved in DNA repair. By inhibiting PARP, ABT-888 prevents cancer cells from repairing damaged DNA, leading to cell death, especially in tumors with deficiencies in other DNA repair pathways, such as BRCA mutations. It is primarily used in cancer research to explore combination therapies, where ABT-888 enhances the efficacy of chemotherapy and radiation treatments. Veliparib is being investigated for its potential in treating various cancers, including breast, ovarian, and lung cancers.
Catalog Number | I005439 |
CAS Number | 912445-05-7 |
Synonyms | ABT-888;ABT888;ABT 888 |
Molecular Formula | C₁₃H₁₆N₄O.2HCl |
Purity | ≥95% |
Target | PARP |
Solubility | DMSO: ≥ 3.2 mg/mL |
Storage | Store at -20°C |
IC50 | 5.2 nM(Ki for PARP1); 2.9 nM(Ki for PARP2) |
IUPAC Name | 2-[(2R)-2-methylpyrrolidin-2-yl]-1H-benzimidazole-4-carboxamide;dihydrochloride |
InChI | InChI=1S/C13H16N4O.2ClH/c1-13(6-3-7-15-13)12-16-9-5-2-4-8(11(14)18)10(9)17-12;;/h2,4-5,15H,3,6-7H2,1H3,(H2,14,18)(H,16,17);2*1H/t13-;;/m1../s1 |
InChIKey | DSBSVDCHFMEYBX-FFXKMJQXSA-N |
SMILES | C[C@@]1(CCCN1)C2=NC3=C(C=CC=C3N2)C(=O)N.Cl.Cl |
Reference | <p> |