Abz-Nle-Lys-Arg-Arg-Ser-3-(NO2)Tyr acetate

• CAT Number: I040034
• Molecular Formula: C43H67N15O12.xC2H4O2
• Molecular Weight: 986.09 (free base)
• Purity: ≥95%

Abz-Nle-Lys-Arg-Arg-Ser-3-(NO₂)Tyr Acetate (Cat No.: I040034) is a fluorogenic peptide substrate used in enzymatic activity assays, particularly for protease and kinase research. The Abz (ortho-aminobenzoic acid) fluorophore and 3-nitrotyrosine (NO₂-Tyr) quencher enable fluorescence-based detection of proteolytic cleavage events. This peptide is valuable in studying serine proteases, including trypsin-like and thrombin-like enzymes, in cancer, inflammation, and cardiovascular research. The acetate form enhances solubility and stability for in vitro applications, making it a key tool in biochemical and drug discovery studies.

Reference

[1]. Christoph Nitsche, et al. Retro peptide-hybrids as selective inhibitors of the Dengue virus NS2B-NS3 protease, Antiviral Research,Volume 94, Issue 1,2012,Pages 72-79.