For research use only. Not for therapeutic Use.
AC-099 hydrochloride (compound 3) is a selective NPFF2R full agonist (EC50=1189 nM) and NPFF1R partial agonist (EC50=2370 nM). AC-099 hydrochloride attenuates spinal nerve ligation-induced hypersensitivity in rats[1][2].
AC-099 hydrochloride (compound 3; 30 mg/kg; i.p.; single) completely attenuates spinal nerve ligation (SNL)-induced hypersensitivity in rats[2].
| Catalog Number | I041130 |
| CAS Number | 849335-07-5 |
| Synonyms | 2-[(E)-[4-chloro-3-(trifluoromethyl)phenyl]methylideneamino]guanidine;hydrochloride |
| Molecular Formula | C9H9Cl2F3N4 |
| Purity | ≥95% |
| InChI | InChI=1S/C9H8ClF3N4.ClH/c10-7-2-1-5(4-16-17-8(14)15)3-6(7)9(11,12)13;/h1-4H,(H4,14,15,17);1H/b16-4+; |
| InChIKey | OMYOUCJVJYJITH-CQCNNJTASA-N |
| SMILES | C1=CC(=C(C=C1C=NN=C(N)N)C(F)(F)F)Cl.Cl |
| Reference | [1]. Findeisen M, et al. Selective mode of action of guanidine-containing non-peptides at human NPFF receptors. J Med Chem. 2012 Jul 12;55(13):6124-36. [2]. Gaubert G, et al. Discovery of selective nonpeptidergic neuropeptide FF2 receptor agonists. J Med Chem. 2009 Nov 12;52(21):6511-4. |
