For research use only. Not for therapeutic Use.
AC-263093 (AC-093) functionally activates NPFFR2 and blocks activation of NPFFR1 with pKis of 6.9 and 7.0, respectively. AC-263093 has the potential for reversing opiate tolerance research[1]. .
AC-263093 (10 mg/kg; i.p.) totally reverses the tolerance to Morphine Sulfate in rats[1].
| Catalog Number | I040090 |
| CAS Number | 849459-86-5 |
| Synonyms | 2-[(E)-(3,4-dibromophenyl)methylideneamino]guanidine |
| Molecular Formula | C8H8Br2N4 |
| Purity | ≥95% |
| InChI | InChI=1S/C8H8Br2N4/c9-6-2-1-5(3-7(6)10)4-13-14-8(11)12/h1-4H,(H4,11,12,14)/b13-4+ |
| InChIKey | VMYFCUKMGMFQNH-YIXHJXPBSA-N |
| SMILES | C1=CC(=C(C=C1C=NN=C(N)N)Br)Br |
| Reference | [1]. David H Malin, et al. Reversal of morphine tolerance by a compound with NPFF receptor subtype-selective actions. Neurosci Lett. 2015 Jan 1:584:141-5. |
