AC-55541

• CAT Number: I005465
• CAS Number: 916170-19-9
• Molecular Formula: C25H20BrN5O3
• Molecular Weight: 518.371
• Purity: ≥95%
• Synonyms: AC55541
• Target: Protease Activated Receptor (PAR)
• Solubility: DMSO: ≥ 51 mg/mL
• Storage: Store at -20C
• IC50: 200-1000 nM(EC50)
• IUPAC Name: N-[2-[(2E)-2-[1-(3-bromophenyl)ethylidene]hydrazinyl]-2-oxo-1-(4-oxo-3H-phthalazin-1-yl)ethyl]benzamide
• InChI: InChI=1S/C25H20BrN5O3/c1-15(17-10-7-11-18(26)14-17)28-31-25(34)22(27-23(32)16-8-3-2-4-9-16)21-19-12-5-6-13-20(19)24(33)30-29-21/h2-14,22H,1H3,(H,27,32)(H,30,33)(H,31,34)/b28-15+
• InChIKey: UCUHFWIFSHROPY-RWPZCVJISA-N
• SMILES: CC(=NNC(=O)C(C1=NNC(=O)C2=CC=CC=C21)NC(=O)C3=CC=CC=C3)C4=CC(=CC=C4)Br

AC-55541 (CAT: I005465) is a small-molecule agonist of protease-activated receptor 2 (PAR2). PAR2 is a G-protein coupled receptor involved in various cellular processes, including inflammation, pain sensation, and tissue repair. AC-55541 activates PAR2 signaling, leading to cellular responses such as proliferation, phosphatidylinositol hydrolysis, and calcium mobilization. The potency of AC-55541 in these assays ranges from 200 to 1000 nM, indicating its ability to activate PAR2-mediated signaling pathways.

Reference

[1]. Gardell LR, et al. Identification and characterization of novel small-molecule protease-activated receptor 2 agonists. J Pharmacol Exp Ther. 2008 Dec;327(3):799-808.