For research use only. Not for therapeutic Use.
AC-55649 is a potent, highly isoform-selective agonist of human RARβ2 receptor, with a pEC50 of 6.9.
AC-55649 is a potent, highly isoform-selective agonist at the human RARβ2 receptor, with a pEC50 of 6.9[1]. AC-55649 is a potent and selective activator of RARβ2 transcriptional activity[2].
| Catalog Number | I001044 |
| CAS Number | 59662-49-6 |
| Synonyms | 4-(4-octylphenyl)benzoic acid |
| Molecular Formula | C21H26O2 |
| Purity | ≥95% |
| InChI | InChI=1S/C21H26O2/c1-2-3-4-5-6-7-8-17-9-11-18(12-10-17)19-13-15-20(16-14-19)21(22)23/h9-16H,2-8H2,1H3,(H,22,23) |
| InChIKey | HXBKPYIEQLLNBK-UHFFFAOYSA-N |
| SMILES | CCCCCCCCC1=CC=C(C=C1)C2=CC=C(C=C2)C(=O)O |
| Reference | [1]. Lund BW, et al. Discovery of a potent, orally available, and isoform-selective retinoic acid beta2 receptor agonist. J Med Chem. 2005 Dec 1;48(24):7517-9. [2]. Piu F, et al. Identification of novel subtype selective RAR agonists. Biochem Pharmacol. 2005 Dec 19;71(1-2):156-62. |
