For research use only. Not for therapeutic Use.
Ac-Arg-Gly-Lys(Ac)-AMC is a substrate for HDAC[1].
Following initial inhibition of HDACs, the peptide substrate Ac-Arg-Gly-Lys-AMC is added to the reaction tubes for next 30 min and finally the stop solution stopped the reaction mediated by HDAC enzymes[1].
Catalog Number | I001015 |
CAS Number | 660846-97-9 |
Synonyms | (2S)-6-acetamido-2-[[2-[[(2S)-2-acetamido-5-(diaminomethylideneamino)pentanoyl]amino]acetyl]amino]-N-(4-methyl-2-oxochromen-7-yl)hexanamide |
Molecular Formula | C28H40N8O7 |
Purity | ≥95% |
InChI | InChI=1S/C28H40N8O7/c1-16-13-25(40)43-23-14-19(9-10-20(16)23)35-27(42)22(7-4-5-11-31-17(2)37)36-24(39)15-33-26(41)21(34-18(3)38)8-6-12-32-28(29)30/h9-10,13-14,21-22H,4-8,11-12,15H2,1-3H3,(H,31,37)(H,33,41)(H,34,38)(H,35,42)(H,36,39)(H4,29,30,32)/t21-,22-/m0/s1 |
InChIKey | HABKINWCDDLXSZ-VXKWHMMOSA-N |
SMILES | CC1=CC(=O)OC2=C1C=CC(=C2)NC(=O)C(CCCCNC(=O)C)NC(=O)CNC(=O)C(CCCN=C(N)N)NC(=O)C |
Reference | [1]. Meike Kespohl, et al. The Microbial Metabolite Butyrate Induces Expression of Th1-Associated Factors in CD4 + T Cells Front Immunol. 2017 Aug 28;8:1036. |