For research use only. Not for therapeutic Use.
Ac-IHIHIQI-NH2 is a fibril-forming heptapeptide with high catalytic activity to laccase mimics. Ac-IHIHIQI-NH2 exhibits selectivity for hydrophobic p-nitrophenyl (ONp) ester substrates in the process of self-assembly[1][2].
Ac-IHIHIQI-NH2 catalyzes p-nitrophenyl acetate (pNPA) hydrolysis in the presence of Zn2+ with a kcat/KM of 62 M-1s-1 at pH 8[2].
| Catalog Number | I041855 |
| CAS Number | 1582727-85-2 |
| Synonyms | (2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S,3S)-2-acetamido-3-methylpentanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-3-methylpentanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-3-methylpentanoyl]amino]-N-[(2S,3S)-1-amino-3-methyl-1-oxopentan-2-yl]pentanediamide |
| Molecular Formula | C43H71N13O9 |
| Purity | ≥95% |
| InChI | InChI=1S/C43H71N13O9/c1-10-22(5)33(37(45)59)54-38(60)29(14-15-32(44)58)51-42(64)35(24(7)12-3)55-40(62)31(17-28-19-47-21-49-28)53-43(65)36(25(8)13-4)56-39(61)30(16-27-18-46-20-48-27)52-41(63)34(23(6)11-2)50-26(9)57/h18-25,29-31,33-36H,10-17H2,1-9H3,(H2,44,58)(H2,45,59)(H,46,48)(H,47,49)(H,50,57)(H,51,64)(H,52,63)(H,53,65)(H,54,60)(H,55,62)(H,56,61)/t22-,23-,24-,25-,29-,30-,31-,33-,34-,35-,36-/m0/s1 |
| InChIKey | SRDUKHXVGZIJNH-MOXZKRHZSA-N |
| SMILES | CCC(C)C(C(=O)N)NC(=O)C(CCC(=O)N)NC(=O)C(C(C)CC)NC(=O)C(CC1=CN=CN1)NC(=O)C(C(C)CC)NC(=O)C(CC2=CN=CN2)NC(=O)C(C(C)CC)NC(=O)C |
| Reference | [1]. Liu Q, et al. Supramolecular enzyme-mimicking catalysts self-assembled from peptides. iScience. 2022 Dec 20;26(1):105831. [2]. Heier JL, et al. Substrate specificity of an actively assembling amyloid catalyst. Biopolymers. 2017 Jan;108(1). |
