For research use only. Not for therapeutic Use.
Ac-PLVE-FMK (Ac-Pro-Leu-Val-Glu(OMe)-CH2F), a tetrapeptidyl m-FMKs, is a Cats inhibitor. Ac-PLVE-FMK can be used for the research of cancer[1].
Ac-PLVE-FMK can efficiently inhibit the activity of Cat-B and Cat-L in the target-based assay (human recombinant enzymes) [1].
Ac-PLVE-FMK can penetrate the cell membrane in the cell-based assay on two human renal cancer cell lines (769-P and A498) [1].
| Catalog Number | I041137 |
| CAS Number | 2679825-26-2 |
| Synonyms | methyl (4S)-4-[[(2S)-2-[[(2S)-2-[[(2S)-1-acetylpyrrolidine-2-carbonyl]amino]-4-methylpentanoyl]amino]-3-methylbutanoyl]amino]-6-fluoro-5-oxohexanoate |
| Molecular Formula | C25H41FN4O7 |
| Purity | ≥95% |
| InChI | InChI=1S/C25H41FN4O7/c1-14(2)12-18(28-24(35)19-8-7-11-30(19)16(5)31)23(34)29-22(15(3)4)25(36)27-17(20(32)13-26)9-10-21(33)37-6/h14-15,17-19,22H,7-13H2,1-6H3,(H,27,36)(H,28,35)(H,29,34)/t17-,18-,19-,22-/m0/s1 |
| InChIKey | IFDBYWWLFGYDSR-OZIGNCPNSA-N |
| SMILES | CC(C)CC(C(=O)NC(C(C)C)C(=O)NC(CCC(=O)OC)C(=O)CF)NC(=O)C1CCCN1C(=O)C |
| Reference | [1]. Citarella A, et al. Peptidyl Fluoromethyl Ketones and Their Applications in Medicinal Chemistry. Molecules. 2020;25(17):4031. Published 2020 Sep 3. |
