For research use only. Not for therapeutic Use.
Ac-PLVE-FMK（Cat No.:I041137）is a synthetic peptide inhibitor that targets caspases, specifically caspase-3, -7, and -8, which are crucial enzymes involved in apoptosis (programmed cell death). The inhibitor is a fluoromethylketone (FMK) derivative, enabling it to irreversibly bind to and block the activity of these caspases, preventing cellular apoptosis. Ac-PLVE-FMK is commonly used in research to study cell death mechanisms, especially in cancer, neurodegenerative diseases, and other conditions where apoptosis is dysregulated. It serves as a valuable tool for investigating the therapeutic potential of caspase inhibition in disease models.
| CAS Number | 2679825-26-2 |
| Synonyms | methyl (4S)-4-[[(2S)-2-[[(2S)-2-[[(2S)-1-acetylpyrrolidine-2-carbonyl]amino]-4-methylpentanoyl]amino]-3-methylbutanoyl]amino]-6-fluoro-5-oxohexanoate |
| Molecular Formula | C25H41FN4O7 |
| Purity | ≥95% |
| IUPAC Name | methyl (4S)-4-[[(2S)-2-[[(2S)-2-[[(2S)-1-acetylpyrrolidine-2-carbonyl]amino]-4-methylpentanoyl]amino]-3-methylbutanoyl]amino]-6-fluoro-5-oxohexanoate |
| InChI | InChI=1S/C25H41FN4O7/c1-14(2)12-18(28-24(35)19-8-7-11-30(19)16(5)31)23(34)29-22(15(3)4)25(36)27-17(20(32)13-26)9-10-21(33)37-6/h14-15,17-19,22H,7-13H2,1-6H3,(H,27,36)(H,28,35)(H,29,34)/t17-,18-,19-,22-/m0/s1 |
| InChIKey | IFDBYWWLFGYDSR-OZIGNCPNSA-N |
| SMILES | CC(C)C[C@@H](C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(=O)OC)C(=O)CF)NC(=O)[C@@H]1CCCN1C(=O)C |
