For research use only. Not for therapeutic Use.
Ac-VLPE-FMK（Cat No.:I041136）is a selective caspase inhibitor that targets caspase-1, an enzyme crucial in the inflammatory response and activation of pyroptosis, a form of programmed cell death. The inhibitor, a fluoromethylketone (FMK) derivative, irreversibly binds to and inhibits the enzymatic activity of caspase-1, thereby preventing inflammation and cell death. Ac-VLPE-FMK is used in research to investigate the role of caspase-1 in diseases such as inflammatory conditions, autoimmune disorders, and infections. Its ability to modulate pyroptosis makes it a potential tool for exploring therapeutic interventions in inflammation-related diseases.
| CAS Number | 2679825-27-3 |
| Synonyms | methyl (4S)-4-[[(2S)-1-[(2S)-2-[[(2S)-2-acetamido-3-methylbutanoyl]amino]-4-methylpentanoyl]pyrrolidine-2-carbonyl]amino]-6-fluoro-5-oxohexanoate |
| Molecular Formula | C25H41FN4O7 |
| Purity | ≥95% |
| IUPAC Name | methyl (4S)-4-[[(2S)-1-[(2S)-2-[[(2S)-2-acetamido-3-methylbutanoyl]amino]-4-methylpentanoyl]pyrrolidine-2-carbonyl]amino]-6-fluoro-5-oxohexanoate |
| InChI | InChI=1S/C25H41FN4O7/c1-14(2)12-18(29-24(35)22(15(3)4)27-16(5)31)25(36)30-11-7-8-19(30)23(34)28-17(20(32)13-26)9-10-21(33)37-6/h14-15,17-19,22H,7-13H2,1-6H3,(H,27,31)(H,28,34)(H,29,35)/t17-,18-,19-,22-/m0/s1 |
| InChIKey | MDAFONIYDVLMOY-OZIGNCPNSA-N |
| SMILES | CC(C)C[C@@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)OC)C(=O)CF)NC(=O)[C@H](C(C)C)NC(=O)C |
