For research use only. Not for therapeutic Use.
Ac-VLPE-FMK, a tetrapeptidyl mono-fluoromethyl ketone (m-FMK), is a Cat-B and Cat-L inhibitor. Ac-VLPE-FMK can be used for the research of cancer aggressiveness[1][2].
Ac-VLPE-FMK (2 μM) significantly affects the cleavage of probe Ac-PLVQ-AMC by human recombinant CtsB and L[1].
Ac-VLPE-FMK (30 min) inhibits the generation of the fluorescence derived from the cleavage of the substrate Ac-PLVQ-AMC in 769-p and A498 cells[1].
Ac-VLPE-FMK (2.5-250 μM; 24-72 h) does not affect renal cancer cell viability, but influences cell migration rate, cellular adhesion, colony formation, and markers expression in renal cancer cells[1].
| Catalog Number | I041136 |
| CAS Number | 2679825-27-3 |
| Synonyms | methyl (4S)-4-[[(2S)-1-[(2S)-2-[[(2S)-2-acetamido-3-methylbutanoyl]amino]-4-methylpentanoyl]pyrrolidine-2-carbonyl]amino]-6-fluoro-5-oxohexanoate |
| Molecular Formula | C25H41FN4O7 |
| Purity | ≥95% |
| InChI | InChI=1S/C25H41FN4O7/c1-14(2)12-18(29-24(35)22(15(3)4)27-16(5)31)25(36)30-11-7-8-19(30)23(34)28-17(20(32)13-26)9-10-21(33)37-6/h14-15,17-19,22H,7-13H2,1-6H3,(H,27,31)(H,28,34)(H,29,35)/t17-,18-,19-,22-/m0/s1 |
| InChIKey | MDAFONIYDVLMOY-OZIGNCPNSA-N |
| SMILES | CC(C)CC(C(=O)N1CCCC1C(=O)NC(CCC(=O)OC)C(=O)CF)NC(=O)C(C(C)C)NC(=O)C |
| Reference | [1]. Rudzińska M, et, al. Cysteine Cathepsins Inhibition Affects Their Expression and Human Renal Cancer Cell Phenotype. Cancers (Basel). 2020 May 21;12(5):1310. [2]. Citarella A, et, al. Peptidyl Fluoromethyl Ketones and Their Applications in Medicinal Chemistry. Molecules. 2020 Sep 3;25(17):4031. |
