Ac-VLPE-FMK

For research use only. Not for therapeutic Use.

  • CAT Number: I041136
  • CAS Number: 2679825-27-3
  • Molecular Formula: C25H41FN4O7
  • Molecular Weight: 528.61
  • Purity: ≥95%
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Ac-VLPE-FMK(Cat No.:I041136)is a selective caspase inhibitor that targets caspase-1, an enzyme crucial in the inflammatory response and activation of pyroptosis, a form of programmed cell death. The inhibitor, a fluoromethylketone (FMK) derivative, irreversibly binds to and inhibits the enzymatic activity of caspase-1, thereby preventing inflammation and cell death. Ac-VLPE-FMK is used in research to investigate the role of caspase-1 in diseases such as inflammatory conditions, autoimmune disorders, and infections. Its ability to modulate pyroptosis makes it a potential tool for exploring therapeutic interventions in inflammation-related diseases.


CAS Number 2679825-27-3
Synonyms

methyl (4S)-4-[[(2S)-1-[(2S)-2-[[(2S)-2-acetamido-3-methylbutanoyl]amino]-4-methylpentanoyl]pyrrolidine-2-carbonyl]amino]-6-fluoro-5-oxohexanoate

Molecular Formula C25H41FN4O7
Purity ≥95%
IUPAC Name methyl (4S)-4-[[(2S)-1-[(2S)-2-[[(2S)-2-acetamido-3-methylbutanoyl]amino]-4-methylpentanoyl]pyrrolidine-2-carbonyl]amino]-6-fluoro-5-oxohexanoate
InChI InChI=1S/C25H41FN4O7/c1-14(2)12-18(29-24(35)22(15(3)4)27-16(5)31)25(36)30-11-7-8-19(30)23(34)28-17(20(32)13-26)9-10-21(33)37-6/h14-15,17-19,22H,7-13H2,1-6H3,(H,27,31)(H,28,34)(H,29,35)/t17-,18-,19-,22-/m0/s1
InChIKey MDAFONIYDVLMOY-OZIGNCPNSA-N
SMILES CC(C)C[C@@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)OC)C(=O)CF)NC(=O)[C@H](C(C)C)NC(=O)C

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