For research use only, not for therapeutic use.
Ac-YVAD-CMK is a selective, irreversible inhibitor of interleukin-<wbr></wbr>1β converting enzyme (ICE; Caspase-<wbr></wbr>1). Ac-<wbr></wbr>YVAD-<wbr></wbr>CMK is neuroprotective in a rat model of cerebral ischemia.
| Catalog Number | M045409 |
| CAS Number | 178603-78-6 |
| Synonyms | N-Ac-Tyr-Val-Ala-Asp-CMK |
| Molecular Formula | C24H33ClN4O8 |
| Purity | ≥95% |
| Storage | -20°C |
| IUPAC Name | (3S)-3-[[(2S)-2-[[(2S)-2-[[(2S)-2-acetamido-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylbutanoyl]amino]propanoyl]amino]-5-chloro-4-oxopentanoic acid |
| InChI | InChI=1S/C24H33ClN4O8/c1-12(2)21(24(37)26-13(3)22(35)28-17(10-20(33)34)19(32)11-25)29-23(36)18(27-14(4)30)9-15-5-7-16(31)8-6-15/h5-8,12-13,17-18,21,31H,9-11H2,1-4H3,(H,26,37)(H,27,30)(H,28,35)(H,29,36)(H,33,34)/t13-,17-,18-,21-/m0/s1 |
| InChIKey | UOUBHJRCKHLGFB-DGJUNBOTSA-N |
| SMILES | CC(C)C(C(=O)NC(C)C(=O)NC(CC(=O)O)C(=O)CCl)NC(=O)C(CC1=CC=C(C=C1)O)NC(=O)C |
