Ac-YVAD-pNA

For research use only. Not for therapeutic Use.

  • CAT Number: R028705
  • CAS Number: 149231-66-3
  • Molecular Formula: C29H36N6O10
  • Molecular Weight: 628.63
  • Purity: ≥95%
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Ac-YVAD-pNA(Cat No.:R028705)is a synthetic peptide substrate commonly used in biochemical research to measure caspase-1 activity. The peptide consists of the sequence YVAD (tyrosine-valine-alanine-aspartic acid) conjugated to the chromogenic substrate pNA (p-nitroaniline). Caspase-1 is an enzyme involved in the inflammatory response, particularly in the activation of pro-inflammatory cytokines like IL-1β. Upon cleavage of Ac-YVAD-pNA by caspase-1, pNA is released, which can be quantified by measuring absorbance, allowing researchers to assess caspase-1 activation and its role in inflammation, apoptosis, and other immune-related processes.


CAS Number 149231-66-3
Synonyms

(3S)-3-[[(2S)-2-[[(2S)-2-[[(2S)-2-acetamido-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylbutanoyl]amino]propanoyl]amino]-4-(4-nitroanilino)-4-oxobutanoic acid

Molecular Formula C29H36N6O10
Purity ≥95%
IUPAC Name (3S)-3-[[(2S)-2-[[(2S)-2-[[(2S)-2-acetamido-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylbutanoyl]amino]propanoyl]amino]-4-(4-nitroanilino)-4-oxobutanoic acid
InChI InChI=1S/C29H36N6O10/c1-15(2)25(34-28(42)22(31-17(4)36)13-18-5-11-21(37)12-6-18)29(43)30-16(3)26(40)33-23(14-24(38)39)27(41)32-19-7-9-20(10-8-19)35(44)45/h5-12,15-16,22-23,25,37H,13-14H2,1-4H3,(H,30,43)(H,31,36)(H,32,41)(H,33,40)(H,34,42)(H,38,39)/t16-,22-,23-,25-/m0/s1
InChIKey YDPNOCSPPGFBPX-XNHCRPTKSA-N
SMILES C[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)NC1=CC=C(C=C1)[N+](=O)[O-])NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC2=CC=C(C=C2)O)NC(=O)C

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