For research use only. Not for therapeutic Use.
Ac-YVAD-pNA（Cat No.:R028705）is a synthetic peptide substrate commonly used in biochemical research to measure caspase-1 activity. The peptide consists of the sequence YVAD (tyrosine-valine-alanine-aspartic acid) conjugated to the chromogenic substrate pNA (p-nitroaniline). Caspase-1 is an enzyme involved in the inflammatory response, particularly in the activation of pro-inflammatory cytokines like IL-1β. Upon cleavage of Ac-YVAD-pNA by caspase-1, pNA is released, which can be quantified by measuring absorbance, allowing researchers to assess caspase-1 activation and its role in inflammation, apoptosis, and other immune-related processes.
| CAS Number | 149231-66-3 |
| Synonyms | (3S)-3-[[(2S)-2-[[(2S)-2-[[(2S)-2-acetamido-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylbutanoyl]amino]propanoyl]amino]-4-(4-nitroanilino)-4-oxobutanoic acid |
| Molecular Formula | C29H36N6O10 |
| Purity | ≥95% |
| IUPAC Name | (3S)-3-[[(2S)-2-[[(2S)-2-[[(2S)-2-acetamido-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylbutanoyl]amino]propanoyl]amino]-4-(4-nitroanilino)-4-oxobutanoic acid |
| InChI | InChI=1S/C29H36N6O10/c1-15(2)25(34-28(42)22(31-17(4)36)13-18-5-11-21(37)12-6-18)29(43)30-16(3)26(40)33-23(14-24(38)39)27(41)32-19-7-9-20(10-8-19)35(44)45/h5-12,15-16,22-23,25,37H,13-14H2,1-4H3,(H,30,43)(H,31,36)(H,32,41)(H,33,40)(H,34,42)(H,38,39)/t16-,22-,23-,25-/m0/s1 |
| InChIKey | YDPNOCSPPGFBPX-XNHCRPTKSA-N |
| SMILES | C[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)NC1=CC=C(C=C1)[N+](=O)[O-])NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC2=CC=C(C=C2)O)NC(=O)C |
