AC480 (BMS-599626)

• CAT Number: I004667
• CAS Number: 714971-09-2
• Molecular Formula: C27H27FN8O3
• Molecular Weight: 530.55
• Purity: ≥95%
• Storage: 3 years-20°Cpowder
• SMILES: CC1=C2C(=NC=NN2C=C1NC(=O)OCC3COCCN3)NC4=CC5=C(C=C4)N(N=C5)CC6=CC(=CC=C6)F

AC480 (BMS-599626) is a selective and efficacious inhibitor of HER1 and HER2 with IC50 of 20 nM and 30 nM, ~8-fold less potent to HER4, >100-fold to VEGFR2, c-Kit, Lck, MET etc. Phase 1.

Reference

[1] Wong TW, et al. Clin Cancer Res, 2006, 12(20 Pt 1), 6186-6193.
[2] Torres MA, et al. Invest New Drugs, 2011, 29(4), 554-561.
[3] Haluska P, et al. Mol Cancer Ther, 2008, 7(9), 2589-2598.