For research use only. Not for therapeutic Use.
ACA-28 (compound 2a) is a potent ERK MAPK signaling modulator. ACA-28 selectively inhibits cancer cell growth by inducing apoptosis with ERK hyperactivation
ACA-28 inhibits cell growth of melanoma cells (SK-MEL-28) and normal melanocytes (NHEM), with IC50 values of 5.3 and 10.1 μM, respectively[1].
| Catalog Number | I043503 |
| CAS Number | 948044-25-5 |
| Synonyms | [4-[methoxycarbonyloxy(phenyl)methyl]phenyl] methyl carbonate |
| Molecular Formula | C17H16O6 |
| Purity | ≥95% |
| InChI | InChI=1S/C17H16O6/c1-20-16(18)22-14-10-8-13(9-11-14)15(23-17(19)21-2)12-6-4-3-5-7-12/h3-11,15H,1-2H3 |
| InChIKey | UZLVJKSHIATGCE-UHFFFAOYSA-N |
| SMILES | COC(=O)OC1=CC=C(C=C1)C(C2=CC=CC=C2)OC(=O)OC |
| Reference | [1]. Satoh R, et al. Discovery of new benzhydrol biscarbonate esters as potent and selective apoptosis inducers of human melanomas bearing the activated ERK pathway: SAR studies on an ERK MAPK signaling modulator, ACA-28. Bioorg Chem. 2020 Oct;103:104137. |
