For research use only. Not for therapeutic Use.
Acemetacin is a non-steroidal anti-inflammatory drug and a glycolic acid ester of indometacin that is a cyclooxygenase inhibitor.<br>Acemetacin is less potent than indomethacin in causing a concentration-related inhibition of PGE accumulation in gastric mucosal incubates. Acemetacin is also less potent than indomethacin in reducing gastric 6-keto-PGF1 alpha and TXB2.<br>Acemetacin induces significantly less gastric and intestinal damage than indomethacin in rats pretreated with inhibitors of COX-2 and NOS, despite markedly suppressing COX activity.
| Catalog Number | A000251 |
| CAS Number | 53164-05-9 |
| Synonyms | K-708 |
| Molecular Formula | C21H18ClNO6 |
| Purity | ≥95% |
| Target | COX |
| Solubility | Soluble in DMSO |
| Storage | 3 years -20C powder |
