Acetaminophen

• CAT Number: I000233
• CAS Number: 103-90-2
• Molecular Formula: C8H9NO2
• Molecular Weight: 151.2
• Purity: ≥95%
• Synonyms: 4′-Hydroxyacetanilide, 4-Acetamidophenol, N-(4-Hydroxyphenyl)acetamide, N-Acetyl-4-aminophenol, APAP, Paracetamol
• Target: COX
• Solubility: 100 mM in ethanol；100 mM in DMSO ； methanol：50 mg/ml；
• Storage: Refrigerator
• Related CAS: 16958-94-4 (sodium salt)
• IUPAC Name: N-(4-hydroxyphenyl)acetamide
• InChI: 1S/C8H9NO2/c1-6(10)9-7-2-4-8(11)5-3-7/h2-5,11H,1H3,(H,9,10)
• InChIKey: RZVAJINKPMORJF-UHFFFAOYSA-N
• SMILES: OC1=CC=C(NC(C)=O)C=C1

Acetaminophen(CAT: I000233) is a commonly used over-the-counter analgesic and antipyretic medication. It is also known as paracetamol. Acetaminophen works by inhibiting the synthesis of prostaglandins, substances in the body that are involved in pain perception and fever. It primarily acts on the central nervous system to provide pain relief and reduce fever. Acetaminophen is widely used to alleviate mild to moderate pain and to reduce fever in various conditions such as headaches, muscle aches, toothaches, and common colds. It is generally considered safe when used at recommended doses, but higher doses can cause liver damage.

Overview of Clinical Research

Acetaminophen is a cyclo-oxygenase 2 inhibitors and a CYP 450 enzyme system inhibitor. South Rampart Pharma is available for licensing Acetaminophen analogues in 2020.

Reference

1. Hinz, B., O. Cheremina, and K. Brune, Acetaminophen (paracetamol) is a selective cyclooxygenase-2 inhibitor in man. FASEB J, 2008. 22(2): p. 383-90.

2. Basic Clin Pharmacol Toxicol. 2016 Mar;118(3):184-9. doi: 10.1111/bcpt.12527. Epub 2015 Dec 28.Acetaminophen for Chronic Pain: A Systematic Review on Efficacy.Ennis ZN(1), Dideriksen D(1), Vaegter HB(2)(3), Handberg G(2), Pottegård A(4).

 

Acetaminophen (paracetamol) is the most commonly used analgesic worldwide and recommended as first-line treatment in all pain conditions by WHO. We performed a systematic literature review to evaluate the efficacy of acetaminophen when used for chronic pain conditions. Applying three broad search strategies for acetaminophen use in chronic pain in both Embase and PubMed, 1551 hits were obtained. After cross-reference searches of both trials and 38 reviews, seven studies comparing acetaminophen in continuous dosing regimens of more than 2 weeks with placebo were included. The review was conducted according to the PRISMA guidelines. All studies were conducted in patients with hip- or knee osteoarthritis and six of seven studies had observation periods of less than 3 months. All included studies showed no or little efficacy with dubious clinical relevance. In conclusion, there is little evidence to support the efficacy of acetaminophen treatment in patients with chronic pain conditions. Assessment of continuous efficacy in the many patients using acetaminophen worldwide is recommended.