Acetaminophen metabolite 3-hydroxy-acetaminophen

• CAT Number: I003377
• CAS Number: 37519-14-5
• Molecular Formula: C8H9NO3
• Molecular Weight: 167.16
• Purity: ≥95%
• Target: Drug Metabolite
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C
• IUPAC Name: N-(3,4-dihydroxyphenyl)acetamide
• InChI: InChI=1S/C8H9NO3/c1-5(10)9-6-2-3-7(11)8(12)4-6/h2-4,11-12H,1H3,(H,9,10)
• InChIKey: IPFBMHOMTSBTSU-UHFFFAOYSA-N
• SMILES: CC(=O)NC1=CC(=C(C=C1)O)O

Acetaminophen metabolite 3-hydroxy-acetaminophen (Cat.No:I003377), also known as N-acetyl-p-benzoquinone imine (NAPQI), is a toxic metabolite produced from the metabolism of acetaminophen. NAPQI is responsible for the hepatotoxicity associated with acetaminophen overdose. In normal conditions, NAPQI is rapidly conjugated with glutathione and eliminated from the body. However, when acetaminophen is taken in large doses or for prolonged periods, the liver’s capacity to eliminate NAPQI is overwhelmed, leading to liver damage.