Acetazolamide

• CAT Number: A000097
• CAS Number: 59-66-5
• Molecular Formula: C4H6N4O3S2
• Molecular Weight: 222.30
• Purity: ≥95%
• Synonyms: Diamox
• Target: Carbonic Anhydrase Inhibitor
• Storage: -20°C
• IUPAC Name: N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide
• InChI: InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9)
• InChIKey: BZKPWHYZMXOIDC-UHFFFAOYSA-N
• SMILES: CC(=O)NC1=NN=C(S1)S(=O)(=O)N

Acetazolamide（Cat No.:A000097）is a carbonic anhydrase inhibitor commonly used to treat glaucoma, altitude sickness, and certain types of epilepsy. By inhibiting carbonic anhydrase, acetazolamide reduces the formation of aqueous humor in the eye, lowering intraocular pressure, making it effective for managing glaucoma. It also promotes the excretion of bicarbonate, helping to acidify the blood and counteract respiratory alkalosis at high altitudes, reducing altitude sickness symptoms. Additionally, it has applications in diuretic therapy and specific metabolic conditions, making acetazolamide a versatile drug for multiple therapeutic areas.

Reference

1: Whiteside H, Gandhi A, Ajebo G, Bryan LJ. When Baking Soda Goes on Shortage:
Urine Alkalinization With Acetazolamide and Oral Sodium Bicarbonate. Ann
Pharmacother. 2017 Nov 1:1060028017740598. doi: 10.1177/1060028017740598. [Epub
ahead of print] PubMed PMID: 29094606.

2: Ahmed SE, Khan AH. Acetazolamide: Treatment of Psychogenic Polydipsia. Cureus.
2017 Aug 9;9(8):e1553. doi: 10.7759/cureus.1553. PubMed PMID: 29021925; PubMed
Central PMCID: PMC5633260.

3: Imiela T, Budaj A. Acetazolamide as Add-on Diuretic Therapy in Exacerbations
of Chronic Heart Failure: a Pilot Study. Clin Drug Investig. 2017 Sep 30. doi:
10.1007/s40261-017-0577-1. [Epub ahead of print] PubMed PMID: 28965280.

4: De Bortoli M, Maillet A, Skopinski S, Sassoust G, Constans J, Boulon C.
[Cerebral vasoreactivity: Concordance of breath holding test and acetazolamide
injection in current practice: 20 cases of asymptomatic carotid artery stenosis].
J Med Vasc. 2017 Oct;42(5):272-281. doi: 10.1016/j.jdmv.2017.06.002. Epub 2017
Sep 12. French. PubMed PMID: 28964386.

5: Ernst E, Gatterer H, Burtscher J, Faulhaber M, Pocecco E, Burtscher M.
Erratum: Effects of Low-Dose acetazolamide on exercise performance in simulated
altitude. Int J Physiol Pathophysiol Pharmacol. 2017 Sep 1;9(4):127. eCollection
2017. PubMed PMID: 28951775; PubMed Central PMCID: PMC5592247.

6: Kunieda T, Miyake K, Sakamoto H, Iwasaki Y, Iida S, Morise S, Fujita K,
Nakamura M, Kaneko S, Kusaka H. Leptomeningeal Collaterals Strongly Correlate
with Reduced Cerebrovascular Reactivity Measured by Acetazolamide-challenged
Single-photon Emission Computed Tomography Using a Stereotactic Extraction
Estimation Analysis in Patients with Unilateral Internal Carotid Artery Stenosis.
Intern Med. 2017 Nov 1;56(21):2857-2863. doi: 10.2169/internalmedicine.8397-16.
Epub 2017 Sep 25. PubMed PMID: 28943539.

7: Yang J, Koruza K, Fisher Z, Knecht W, Baltzer L. Improved molecular
recognition of Carbonic Anhydrase IX by polypeptide conjugation to acetazolamide.
Bioorg Med Chem. 2017 Oct 15;25(20):5838-5848. doi: 10.1016/j.bmc.2017.09.017.
Epub 2017 Sep 14. PubMed PMID: 28943245.

8: Rahmoune H, Boutrid N, Gherbi I, Arezki S, Amrane M, Bioud B. Successful
management of MPS hydrocephalus by acetazolamide. Childs Nerv Syst. 2017
Dec;33(12):2075-2076. doi: 10.1007/s00381-017-3597-5. Epub 2017 Sep 19. PubMed
PMID: 28929292.

9: Haller S, Barkhof F, Thomas D, Lovblad KO, Golay X, Zaharchuk G. Further
Implications of Off-Label Use of Acetazolamide in the Management of Moyamoya
Disease in Japan: Response. Radiology. 2017 Jul;284(1):301-303. doi:
10.1148/radiol.2017170252. PubMed PMID: 28896007.

10: Bertone NI, Groisman AI, Mazzone GL, Cano R, Tabares L, Uchitel OD. Carbonic
anhydrase inhibitor acetazolamide shifts synaptic vesicle recycling to a fast
mode at the mouse neuromuscular junction. Synapse. 2017 Dec;71(12). doi:
10.1002/syn.22009. Epub 2017 Sep 21. PubMed PMID: 28873252.