Acetyl-CoA Carboxylase-IN-1

For research use only. Not for therapeutic Use.

  • CAT Number: R027601
  • CAS Number: 179343-23-8
  • Molecular Formula: C13H9Br2N5
  • Molecular Weight: 395.05
  • Purity: ≥95%
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Acetyl-CoA Carboxylase-IN-1 is a potent acetyl-CoA carboxylase (ACC) inhibitor with an IC50 value of <5 nM. Acetyl-CoA Carboxylase-IN-1 has antibacterial activity[1].
Acetyl-CoA Carboxylase-IN-1 (compound 1; 0.012-25 μM; E. coli) has antibacterial activity with MIC values of >25, 3.13, 25, 0.39, 1.56, 0.1 μM for WT, WT+ PMBN, ΔacrAB, ΔacrAB+PMBN, ΔtolC, and ΔtolC+ PMBN, respectively[1].


Catalog Number R027601
CAS Number 179343-23-8
Synonyms

6-(2,6-dibromophenyl)pyrido[2,3-d]pyrimidine-2,7-diamine

Molecular Formula C13H9Br2N5
Purity ≥95%
InChI InChI=1S/C13H9Br2N5/c14-8-2-1-3-9(15)10(8)7-4-6-5-18-13(17)20-12(6)19-11(7)16/h1-5H,(H4,16,17,18,19,20)
InChIKey HGIPWJYTPOHUGK-UHFFFAOYSA-N
SMILES C1=CC(=C(C(=C1)Br)C2=C(N=C3C(=C2)C=NC(=N3)N)N)Br
Reference

[1]. Cifone MT, et, al. Heterobivalent Inhibitors of Acetyl-CoA Carboxylase: Drug Target Residence Time and Time-Dependent Antibacterial Activity. J Med Chem. 2022 Dec 22;65(24):16510-16525. 
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