For research use only. Not for therapeutic Use.
Acetyl-CoA Carboxylase-IN-1 is a potent acetyl-CoA carboxylase (ACC) inhibitor with an IC50 value of <5 nM. Acetyl-CoA Carboxylase-IN-1 has antibacterial activity[1].
Acetyl-CoA Carboxylase-IN-1 (compound 1; 0.012-25 μM; E. coli) has antibacterial activity with MIC values of >25, 3.13, 25, 0.39, 1.56, 0.1 μM for WT, WT+ PMBN, ΔacrAB, ΔacrAB+PMBN, ΔtolC, and ΔtolC+ PMBN, respectively[1].
Catalog Number | R027601 |
CAS Number | 179343-23-8 |
Synonyms | 6-(2,6-dibromophenyl)pyrido[2,3-d]pyrimidine-2,7-diamine |
Molecular Formula | C13H9Br2N5 |
Purity | ≥95% |
InChI | InChI=1S/C13H9Br2N5/c14-8-2-1-3-9(15)10(8)7-4-6-5-18-13(17)20-12(6)19-11(7)16/h1-5H,(H4,16,17,18,19,20) |
InChIKey | HGIPWJYTPOHUGK-UHFFFAOYSA-N |
SMILES | C1=CC(=C(C(=C1)Br)C2=C(N=C3C(=C2)C=NC(=N3)N)N)Br |
Reference | [1]. Cifone MT, et, al. Heterobivalent Inhibitors of Acetyl-CoA Carboxylase: Drug Target Residence Time and Time-Dependent Antibacterial Activity. J Med Chem. 2022 Dec 22;65(24):16510-16525. |