Acetyllovastatin

• CAT Number: I018704
• CAS Number: 81189-92-6
• Molecular Formula: C₂₆H₃₈O₆
• Molecular Weight: 446.58
• Purity: ≥95%
• Target: Fungal
• Storage: Store at -20°C
• IUPAC Name: [(1S,3R,7S,8S,8aR)-8-[2-[(2R,4R)-4-acetyloxy-6-oxooxan-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] (2S)-2-methylbutanoate
• InChI: InChI=1S/C26H38O6/c1-6-16(3)26(29)32-23-12-15(2)11-19-8-7-17(4)22(25(19)23)10-9-20-13-21(30-18(5)27)14-24(28)31-20/h7-8,11,15-17,20-23,25H,6,9-10,12-14H2,1-5H3/t15-,16-,17-,20+,21+,22-,23-,25-/m0/s1
• InChIKey: OYNSFDWALRRTFU-QQVNEASTSA-N
• SMILES: CC[C@H](C)C(=O)O[C@H]1C[C@H](C=C2[C@H]1[C@H]([C@H](C=C2)C)CC[C@@H]3C[C@H](CC(=O)O3)OC(=O)C)C

Acetyllovastatin（Cat No.:I018704）is a potent statin derivative used to lower cholesterol levels and manage hyperlipidemia. It works by inhibiting HMG-CoA reductase, a key enzyme involved in the synthesis of cholesterol in the liver. This reduction in cholesterol production helps lower total cholesterol, LDL cholesterol, and triglycerides while increasing HDL cholesterol. Acetyllovastatin is commonly prescribed to reduce the risk of cardiovascular events, including heart attack and stroke, in patients with high cholesterol. Its effects are beneficial in improving overall lipid profiles and supporting cardiovascular health.

Reference

[1]. Cazar, et al. Antimicrobial Butyrolactone I Derivatives from the Ecuadorian Soil Fungus Aspergillus terreus Thorn. var terreus. World Journal of Microbiology and Biotechnology, 2005,21(6-7), 1067–1075.