For research use only. Not for therapeutic Use.
AChE/BChE-IN-10 (Compound 7b) is a potent dual AChE and BChE inhibitor with IC50 values of 0.176, and 0.47 μM, respectively. AChE/BChE-IN-10 shows good blood brain barrier permeability. AChE/BChE-IN-10 can inhibit Aβ-aggregation and be used in Alzheimer’s disease (AD) research[1].
AChE/BChE-IN-10 inhibits AChE in a non-competitive manner with Ki of 0.21 μM, and BChE in a mixed-fashion with Ki of 0.15 μM[1].
| Catalog Number | I042827 |
| CAS Number | 2924824-48-4 |
| Synonyms | N-[2-(1-benzylpiperidin-4-yl)ethyl]-6-methoxynaphthalene-2-carboxamide |
| Molecular Formula | C26H30N2O2 |
| Purity | ≥95% |
| InChI | InChI=1S/C26H30N2O2/c1-30-25-10-9-22-17-24(8-7-23(22)18-25)26(29)27-14-11-20-12-15-28(16-13-20)19-21-5-3-2-4-6-21/h2-10,17-18,20H,11-16,19H2,1H3,(H,27,29) |
| InChIKey | AIIWJMPOAUNFLG-UHFFFAOYSA-N |
| SMILES | COC1=CC2=C(C=C1)C=C(C=C2)C(=O)NCCC3CCN(CC3)CC4=CC=CC=C4 |
| Reference | [1]. Mohd Abdullaha, et al. Discovery of methoxy-naphthyl linked N-(1-benzylpiperidine) benzamide as a blood-brain permeable dual inhibitor of acetylcholinesterase and butyrylcholinesterase. Eur J Med Chem. 2020 Dec 1;207:112761. |
