AChE/BChE/MAO-B-IN-1

• CAT Number: I043685
• CAS Number: 2416910-82-0
• Molecular Formula: C20H24N2O2
• Molecular Weight: 324.42
• Purity: ≥95%
• Synonyms: (1-benzylpiperidin-4-yl)methyl N-phenylcarbamate
• InChI: InChI=1S/C20H24N2O2/c23-20(21-19-9-5-2-6-10-19)24-16-18-11-13-22(14-12-18)15-17-7-3-1-4-8-17/h1-10,18H,11-16H2,(H,21,23)
• InChIKey: IKTRKOHDYGDICC-UHFFFAOYSA-N
• SMILES: C1CN(CCC1COC(=O)NC2=CC=CC=C2)CC3=CC=CC=C3

AChE/BChE/MAO-B-IN-1 (Compound 10) is a reversible and non-time-dependent AChE, BChE and MAO-B inhibitor with IC50 values of 7.31, 0.56 and 26.1 μM for hAChE, hBChE and hMAO-B, respectively. AChE/BChE/MAO-B-IN-1 can cross the BBB and shows neuroprotective effects without cytotoxicity[1].
AChE/BChE/MAO-B-IN-1 (Compound 10) prevents amyloid β1-42 (Aβ1-42)-induced neuronal cell death[1].

Reference

[1]. Košak U, et al. N-alkylpiperidine carbamates as potential anti-Alzheimer’s agents. Eur J Med Chem. 2020 Jul 1;197:112282.
 [Content Brief]