For research use only. Not for therapeutic Use.
AChE/BuChE-IN-4(compound 4a) is aorally activeandbrain-penetrantmultitarget-directedAChE/BuChEinhibitor againstAChEandBuChE, with theIC50of 2.08 and 7.41 μM[1].
| Catalog Number | I040582 |
| CAS Number | 1997158-25-4 |
| Synonyms | 4-N-[(1-benzylpiperidin-4-yl)methyl]pyrimidine-2,4-diamine |
| Molecular Formula | C17H23N5 |
| Purity | ≥95% |
| InChI | InChI=1S/C17H23N5/c18-17-19-9-6-16(21-17)20-12-14-7-10-22(11-8-14)13-15-4-2-1-3-5-15/h1-6,9,14H,7-8,10-13H2,(H3,18,19,20,21) |
| InChIKey | UOIHYBDULIXVAR-UHFFFAOYSA-N |
| SMILES | C1CN(CCC1CNC2=NC(=NC=C2)N)CC3=CC=CC=C3 |
| Reference | [1]. Conceição RAD, et al. Structure-based design of new N-benzyl-piperidine derivatives as multitarget-directed AChE/BuChE inhibitors for Alzheimer’s disease [published online ahead of print, 2023 Oct 5]. J Cell Biochem. 2023;10.1002/jcb.30483. |
