AChE-IN-26

• CAT Number: I042826
• CAS Number: 2977170-10-6
• Molecular Formula: C21H21BrN2O3
• Molecular Weight: 429.31
• Purity: ≥95%
• Synonyms: N-(1-benzylpyridin-1-ium-4-yl)-3,4-dimethoxybenzamide;bromide
• InChI: InChI=1S/C21H20N2O3.BrH/c1-25-19-9-8-17(14-20(19)26-2)21(24)22-18-10-12-23(13-11-18)15-16-6-4-3-5-7-16;/h3-14H,15H2,1-2H3;1H
• InChIKey: VGTPSQFSPGENRA-UHFFFAOYSA-N
• SMILES: COC1=C(C=C(C=C1)C(=O)NC2=CC=[N+](C=C2)CC3=CC=CC=C3)OC.[Br-]

AChE-IN-26 (compound 4a) is an AChE (acetylcholinesterase) inhibitor with an IC50 value of 0.42 μM. AChE-IN-26 can be used for the research of Alzheimer’s disease[1].
AChE-IN-26 (1 and 10 μM;20 min) shows an in-vitro inhibition to AChE of 91.45%, and inhibits AChE with an IC50 value of 0.42 μM[1].

Reference

[1]. Abdullaha M, et al. Discovery of methoxy-naphthyl linked N-(1-benzylpiperidine) benzamide as a blood-brain permeable dual inhibitor of acetylcholinesterase and butyrylcholinesterase. Eur J Med Chem. 2020 Dec 1;207:112761.
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