AChE-IN-27

• CAT Number: I042886
• CAS Number: 177028-90-9
• Molecular Formula: C20H14N2O3
• Molecular Weight: 330.34
• Purity: ≥95%
• Synonyms: 2-amino-4-(4-methylphenyl)-5-oxo-4H-pyrano[3,2-c]chromene-3-carbonitrile
• InChI: InChI=1S/C20H14N2O3/c1-11-6-8-12(9-7-11)16-14(10-21)19(22)25-18-13-4-2-3-5-15(13)24-20(23)17(16)18/h2-9,16H,22H2,1H3
• InChIKey: VRDLSXTUIVLTTD-UHFFFAOYSA-N
• SMILES: CC1=CC=C(C=C1)C2C(=C(OC3=C2C(=O)OC4=CC=CC=C43)N)C#N

AChE-IN-27 (compound 8c) is an AChE inhibitor (IC50=0.19 µM). AChE-IN-27 can be used in studies of neurological diseases such as alzheimer’s disease, dementia, ataxia and myasthenia gravis[1].

Reference

[1]. Bouazizi Y, et al. Synthesis of new 3, 4-dihydropyrano [c] chromene derivatives and their evaluation as acetyl cholinesterase inhibitors[J]. European Journal of Chemistry, 2014, 5(3): 457-462.