AChE-IN-3

• CAT Number: I045177
• CAS Number: 2713548-95-7
• Molecular Formula: C25H21N3O4
• Molecular Weight: 427.45
• Purity: ≥95%
• Synonyms: [(E)-[1-(2,2-dimethyl-1,3-benzodioxol-5-yl)-2-imidazol-1-ylethylidene]amino] naphthalene-2-carboxylate
• InChI: InChI=1S/C25H21N3O4/c1-25(2)30-22-10-9-19(14-23(22)31-25)21(15-28-12-11-26-16-28)27-32-24(29)20-8-7-17-5-3-4-6-18(17)13-20/h3-14,16H,15H2,1-2H3/b27-21-
• InChIKey: HAHPBHJWRHEGQZ-MEFGMAGPSA-N
• SMILES: CC1(OC2=C(O1)C=C(C=C2)C(=NOC(=O)C3=CC4=CC=CC=C4C=C3)CN5C=CN=C5)C

AChE-IN-3 shows moderate inhibitory activity against AChE and strong NO inhibitory activity with an EC50 of 0.57 μM.

Reference

[1]. Ren B, et al. Imidazolylacetophenone oxime-based multifunctional neuroprotective agents: Discovery and structure-activity relationships. Eur J Med Chem. 2022 Jan 15;228:114031.
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