ACHP Hydrochloride

• CAT Number: I003482
• CAS Number: 406209-26-5
• Molecular Formula: C21H25ClN4O2
• Molecular Weight: 400.9
• Purity: ≥95%
• Synonyms: (6E)-2-amino-6-[2-(cyclopropylmethoxy)-6-oxocyclohexa-2,4-dien-1-ylidene]-4-piperidin-4-yl-1H-pyridine-3-carbonitrile hydrochloride
• Target: IKK
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C
• IC50: 8.5 nM [1]

ACHP Hydrochloride is a potent and selective IKK-2 inhibitor with IC50 of 8.5 nM.IC50 value: 8.5 nM [1]Target: IKK-2ACHP Hydrochloride exhibited excellent in vitro profiles (IKK-beta IC(50)=8.5 nM, Cell IC(50)=60 nM) and a strong oral efficacy in in vivo anti-inflammatory assays (significant effects at 1mg/kg, po in arachidonic acid-induced ear edema model in mice).

Reference

[1]. Murata T, et al. Synthesis and structure-activity relationships of novel IKK-beta inhibitors. Part 3: Orally active anti-inflammatory agents. Bioorg Med Chem Lett. 2004 Aug 2;14(15):4019-22.