Aciclovir

• CAT Number: A001066
• CAS Number: 59277-89-3
• Molecular Formula: C8H11N5O3
• Molecular Weight: 225.2
• Purity: ≥95%
• Synonyms: Aciclovir; Acycloguanosine; 59277-89-3; Zovirax; Vipral
• Target: DNA Synthesis
• Solubility: >11.4mg/mL in DMSO
• Storage: -20°C
• IUPAC Name: 2-amino-9-(2-hydroxyethoxymethyl)-1H-purin-6-one
• InChI: InChI=1S/C8H11N5O3/c9-8-11-6-5(7(15)12-8)10-3-13(6)4-16-2-1-14/h3,14H,1-2,4H2,(H3,9,11,12,15)
• InChIKey: MKUXAQIIEYXACX-UHFFFAOYSA-N
• SMILES: C1=NC2=C(N1COCCO)NC(=NC2=O)N

Acyclovir (CAS 59277-89-3) is an antiviral agent with activity against herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) and varicella zoster virus. Acyclovir is converted by a herpesvirus enzyme into acyclovir triphosphate that inhibits the synthesis of deoxyribonucleic acid (DNA) molecules in the virally infected cells, thereby inhibiting viral replication. It induces apoptosis in cells transfected with HSV-TK (suicidal gene therapy).

Overview of Clinical Research

Acyclovir is a DNA-directed DNA polymerase inhibitor. The preclinical development is ongoing in Israel.

Reference

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