Acid Ceramidase-IN-1

• CAT Number: I045229
• CAS Number: 2415225-30-6
• Molecular Formula: C18H25N3O3
• Molecular Weight: 331.41
• Purity: ≥95%
• Synonyms: 6-(1-methylpiperidin-4-yl)-N-(2-methylpropyl)-2-oxo-1,3-benzoxazole-3-carboxamide
• InChI: InChI=1S/C18H25N3O3/c1-12(2)11-19-17(22)21-15-5-4-14(10-16(15)24-18(21)23)13-6-8-20(3)9-7-13/h4-5,10,12-13H,6-9,11H2,1-3H3,(H,19,22)
• InChIKey: AYXQGWOLRJUITD-UHFFFAOYSA-N
• SMILES: CC(C)CNC(=O)N1C2=C(C=C(C=C2)C3CCN(CC3)C)OC1=O

Acid Ceramidase-IN-1 is a potent and oral bioavailable acid ceramidase (AC, ASAH-1) inhibitor (hAC IC50=0.166 μM). Acid Ceramidase-IN-1 has excellent brain penetration in mice[1].

Reference

[1]. Di Martino S, et al. Lead Optimization of Benzoxazolone Carboxamides as Orally Bioavailable and CNS Penetrant Acid Ceramidase Inhibitors. J Med Chem. 2020;63(7):3634-3664.
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