Acid-PEG2-SS-PEG2-acid

• CAT Number: I016126
• CAS Number: 1807539-10-1
• Molecular Formula: C₁₄H₂₆O₈S₂
• Molecular Weight: 386.48
• Purity: ≥95%
• Target: ADC Linker
• IUPAC Name: 3-[2-[2-[2-[2-(2-carboxyethoxy)ethoxy]ethyldisulfanyl]ethoxy]ethoxy]propanoic acid
• InChI: InChI=1S/C14H26O8S2/c15-13(16)1-3-19-5-7-21-9-11-23-24-12-10-22-8-6-20-4-2-14(17)18/h1-12H2,(H,15,16)(H,17,18)
• InChIKey: TZKZHEPGHNBGKD-UHFFFAOYSA-N
• SMILES: C(COCCOCCSSCCOCCOCCC(=O)O)C(=O)O

Acid-PEG2-SS-PEG2-acid（Cat No.:I016126） is a cleavable linker composed of four polyethylene glycol (PEG) units. It is utilized in the synthesis of antibody-drug conjugates (ADCs). The linker contains a disulfide bond (SS) that can be cleaved under specific conditions, such as the presence of reducing agents, to release the attached drug payload from the antibody. The PEG units provide water solubility and flexibility to the linker, facilitating the conjugation of the drug to the antibody and allowing for controlled drug release at the target site.

Reference

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.