Acid-PEG4-C2-Boc

• CAT Number: I017207
• CAS Number: 1835759-85-7
• Molecular Formula: C₁₆H₃₀O₈
• Molecular Weight: 350.4
• Purity: ≥95%
• Target: PROTAC Linkers

Acid-PEG4-C2-Boc (CAT: I017207) is a linker molecule commonly used in the synthesis of PROTACs (proteolysis-targeting chimeras). PROTACs are bifunctional molecules that consist of a ligand for a target protein, a linker, and a ligand for an E3 ubiquitin ligase. Acid-PEG4-C2-Boc serves as the linker component, connecting the ligands for the target protein and the E3 ligase. In the context of mTOR (mammalian target of rapamycin) inhibition, Acid-PEG4-C2-Boc can be used to design PROTACs that induce the degradation of mTOR protein, providing a strategy for modulating mTOR signaling pathways.

Reference

[1]. Jennifer PITZEN , et al. C40-, c28-, and c-32-linked rapamycin analogs as mtor inhibitors. WO2019212990A1.